Paper Information

Title: 

EVALUATION OF THE EFFECTS OF A DIBENZODIAZEPINE DERIVATIVE (CLOZAPINE) ON MEMORY RETRIEVAL AND RETENTION IN MOUSE

Type: PAPER
Author(s): MIKAEILI P.*,ZAEIMZADEH N.,ARZI A.
 
 *DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, SCHOOL OF PHARMACY, AHWAZ JUNDISHAPOUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Clozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. But their effect on memory has not yet been broadly investigated. In this study, we have evaluated its effects on memory retention and retrieval.
Methods: Male Wistar albino mice (n=80) were weighted, labeled and grouped as follows: (a) sham group received electrical shock (ES) plus normal saline (NS); (b) control group underwent only ES; (c, d and e) test groups 1 through 3 received ES plus 1, 2 and 3mg/kg of Clozapine, respectively. For retention study groups (n=40) Clozapine was injected immediately and for retrieval study groups (n=40) 23.5 hours after ES. In all groups, step-down latency was measured.
Results: The result of this study indicated that the mean of step-down latency of day 4 in comparison with day 2 became longer (p<0.05) in all groups. Clozapine-treated mice groups in comparison to the control and sham groups did not show any significant difference in step-down latency on day 4 (p>0.05).
Conclusion: The results indicated no significant improvement in cognitive function in Clozapine-treated animals.

 
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