Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

STUDY OF PAIN BEHAVIORS IN TWO PERIPHERAL NEUROPATHIC MODELS (SNI, CCI) IN RAT

Type: POSTER
Author(s): MIRZAEI V.*,MANAHEJI H.,KERAMATI K.,MAGHSOUDI N.,ZARIN GHALAM MOGHADAM JALAL
 
 *NEUROSCIENSE RESEARCH CENTER, SHAHEED BEHESHTI MEDICAL SCIENCES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Peripheral nerve injury could result neuropathic pain syndroms, including allodynia and hyperalgesia. There are different neuropathic models in animals to study the mechanism of neuropathic pain ,the present experiment are performed on two models, Chronic Constriction Injury (CCI) and Spared Nerve Injury (SNI).
Methods: Male Sprague-Dawely rats (180-220g) were initial anesthetized with ketamin-xylasin. CCI models was
made by 4 ligation on sciatic nerve. SNI models involve two of terminal branches of sciatic nerve. At 4, 7 and 14 days after ligation thermal hyperalgesia and mechano allodynia was assessed.
Results: The results indicated that comparison of sham with SNI and CCI group’s revealed significant differences in allodynia and hyperalgesia at day 7th and 14th (p≤0.001). The sensivithy were prominent at 14 and 4 day after ligation. In comparison of SNI and CCI groups there was no significant difference in pain behaviers, However the SNI rats were more sensitive rats to allodynia than the CCI rats, and also the CCI rats were more sensitive to hyperalgesia than SNI rats.
Conclusion: The CCI and SNI neuropathic models demonstrated the exaggerated the sensitivity to both non pain full thermal and mechanical stimular following nerve injury both the intensity of responces were different in CCI and SNI models.

 
Keyword(s): 
 
 
Yearly Visit 41   tarjomyar
 
Latest on Blog
Enter SID Blog