Paper Information

Title: 

HISTOLOGICAL ASSESSMENT OF ANTERIOR LOBE OF PITUITARY GLAND IN MORPHINE DEPENDENT AND NON-DEPENDENT RATS

Type: POSTER
Author(s): MIRHOSSEINI M.,EZATABADIPOUR M.,DABIRI SH.,REZAEIZADEH A.R.,EFTEKHAR VAGHEFI S.H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Pituitary gland by the help of secretion of stimulating hormones is undertaking for the control of secretion of thAe other glands hormones. The effect of adenohypophysis hormone is somehow a known subject. However, a few researches about the effects of opioids on the morphology of pituitary have been carried out. In this study the effect of morphine on adenohypophysis cells is studied.
Methods: This study has been carried out on 12 adults male wistar rats in which they were addicted through consumption of morphine (edible and solution in water) during 12 days. After control of withdrawal syndrome signs, animal’s blood were tested and the amount of prolactin was calculated by applying Elisa method. In the preceding step after anesthetized the animals and performing cardiac perfusion, animal’s hypophysis were removed and fixed at %10 formalin. Then immunohistochemistry staining was done for recognition of the secretary origin of cells. The numbers of lactotroph and somatotroph cells in two groups were evaluated.
Results: The mean of prolactin production in dependent group as compared with independent group showed significant difference. The results of immunohistochemistry method showed significant increase in the number of morphine dependent mamotroph cells in comparison with independent group.
Conclusion: In previous studies, some paradoxical information was distributed about the effect of morphine on adenohypophysis hormones. In conclusion this research is denoted of effect of addiction on lactotroph cells is significant increase in anterior lobe of hypophysis which is responsible for prolactin.

 
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