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Paper Information

Title: 

EFFECT OF INHALATION ETHANOLIC EXTRACT OF PEGANUM HARMALA ON FEAR BY ELEVATED PLUS-MAZE

Type: POSTER
Author(s): VAEZI GH.H.,ORYAN SHAHRBANOU,ETEMADI L.,MANAFI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In this investigation according to the extensive application of Peganum harmala seeds in the Asia. In order to recognition of behavioral effects, its inhalation was evaluated on adult male rats.
Method: Humidity of ethanolic extract (ETE) was 37% wet. Animals (n=6 in each group) intake 2, 4, 6, 12, 18mg/ml doses from ETE by using Nebulizer, separately. The Elevated Plus-Maze apparatus is used for evaluating the fear behavior. Harmaline drug (0.13mg/ml) is chosen as positive control.
Results: Data were given positive control group of evaluated fear behavioral by Elevated Plus-Maze. In compare with saline, shown Harmaline may be successfully caused fear in rats by increased time spent in close arm, significantly (p<0.05). Also ETE from P.h may be able to show this effect in 6, 12, 18mg/ml doses more effective saline (p<0.05).
Discussion: In final authors suggested more studies on mechanism effect of P.h extract on fear behavior.

 
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