Paper Information

Title:  CARDIOVASCULAR RESPONSE TO INJECTION OF ACETYLCHOLINE INTO THE BED NUCLEUS OF THE STRIA TERMINALS OF RAT
Type: POSTER
Author(s): MORADI A.M.,RAVARI M.,HATAM M.,NASIMI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The bed nucleus of the stria terminals (BST) is a part of the limbic system. The presence of the cholinergic neurons in the BST has been demonstrated but the role of these neurons in the cardiovascular regulation has not been yet investigated. This study was performed to find the role of the cholinergic muscarinic receptors in the cardiovascular regulation of the BST. Drugs (50nl) were microinjected into the BST of urethane anaesthetized rats and the blood pressure and heart rate were recorded before and throughout each experiment. Microinjection of acetylcholine chloride (30, 60nmole) into the dorsal part of the BST caused dose-dependent of hypertensive responses (Emax=17.35±1.4) with no significant change of the heart rate. The hypertensive response of acetylcholine chloride was blocked when muscarinic receptors blocker atropine methyl bromide (10nmol) was microinjected to the BST. On the other hand administration of atropine (intravenous) abolished the pressor response to microinjection of acetylcholine into the BST. This study indicated that the BST muscarinic receptors mediate a hypertensive response without a change in heart rate.

 
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