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Paper Information

Title: 

EXAMINATION OF THE EXTRACELLULAR ZINC (VOLTAGE DEPENDENT AND VOLTAGE IN DEPENDED) EFFECT ON THE PASSIVE AVOIDANCE LEARNING IN MALE VISTA RATS

Type: POSTER
Author(s): MOHAJERANI H.,PALIZVAN M.R.,ORYAN SHAHRBANOU,BABAPOUR V.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Because of neuromodulatory role of extracellular zinc in limbic system, striatum and forebrain in nervous system and its entrance is dependent to voltage sensitive channels, decided to examination zinc male vista rats.
Methods: Effect of calcium channel antagonists and zinc chelator, Ca-EDTA on passive avoidance learning (shuttle box apparatus) by i.c.v administration of different doses of this drugs examined. Injection of drugs performed as retraining, post-training and pretest.
Result: Result of i.c.v injection of the Ca-EDTA indicated that by 100milimolar injection of this drug has no effect on the acquisition, consolidation, and retrieval pf passive avoidance learning. Verapamil (100 and 150 microgram) as a L-type voltage gated calcium channel antagonist decreased acquisition and consolidation but not retrieval of the passive avoidance behaviour. These effects were dose dependent. The simultaneous effect of Ca-EDTA and verapamil also studied. Ca-EDTA (100 milimolar) and verapamil (100 microgram) have negative effect on consolation of the passive avoidance learning.
Conclusion: probably, common mechanisms involve in acquisition and consolidation pf passive avoidance learning that zinc and calcium ions play interactive role in this aspect.

 
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