Paper Information

Title: 

EFFECT OF HISTAMINE AND SCOPOLAMINE ON WATER INTAKE IN ADULT MALE RATS

Type: POSTER
Author(s): NABIOUN F.,EYDI A.,EYDI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Histamine can be found in a restricted population of neurons originating from the tuberomammillary nucleus and projecting diffusely to several brain areas. The three subtypes of histamine receptors (H1, H2 and H3) are distributed in almost all parts of the brain of mammalian species. Central histaminergic neurons have been implicated in many physiological processes, such as circadian rhythms, thermoregulation, learning and memory and cardiovascular and neuroendocrine regulation. It is unclear whether endogenous histamine is involved in the regulation of water balance. Furthermore, in addition to its well-documented modulation of food intake, the cholinergic system also plays a role in water intake. The present study investigated the effects of histaminergic receptors and muscarinic cholinoceptors on water intake in adult male rats. Intraperitoneally (i.p.) injections were carried out in all experiments after 24-h deprivation of water. After deprivation, the volume of consumed water was measured for 1 h. Administration histamine (1-5mg/kg wt.) increased, while scopolamine, a muscarinic cholinoceptor antagonist (0.01-1mg/kg wt.) decreased water intake in isolated rats. It is concluded that histaminergic and muscarinic cholinergic systems may interact on water intake. It is suggested that angiotensinergic system might involved in this process.

 
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