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Paper Information

Title: 

STUDY OF PHYTOESTROGENIC EFFECT OF MATRICARIA RECUTITA ON LOCOMOTOR ACTIVITY IN PRESENCE AND ABSENCE OF GONADS

Type: POSTER
Author(s): KESMATI M.,NAGHSH JAVAHERI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: It has been shown that the estrogens affect the locomotor activity in animal. Considering presence of phytoestrogenic components in Matricaria recutita (MR), and possible interaction with endogenous estrogens, the aim of this investigation was the study of MR effect on locomotor activity parameters in the presence and absence of tamoxifen (as an estrogenic receptors antagonist) and gonads.
Method: NMRI adult mice weighted 32±3 grams were used .Groups were divided into: intact, sham and ovarectomized mice that received: 1) saline, 2) MR (50mg/kg), 3) tamoxifen (0.1, 0.5, 0.75mg/kg), 4) saline+ MR, 5) tamoxifen (0.5mg/kg) +MR. Motor activity monitor was used for locomotor activity evaluation. Six locomotor parameters such as fast and slow activity, fast and slow stereotype activity and fast and slow rearing were measured.
Results: 1) MR increased significantly the fast activity and slow rearing in intact female mice. 2) MR did not change locomotor activity parameters in ovarectomized female mice. 3) Tamoxifen (0.5mg/kg) decreased fast and slow activity in intact mice. 4) Tamoxifen (0.5mg/kg) in presence of MR decreased most of locomotor activity parameters in intact mice but had no effects in ovarectomized mice: It seems MR affects some locomotor activity parameters via the estrogenic receptors, and the presences of endogenous sex hormones are essential for action of its phytoestrogenic components.

 
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