Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

EFFECT OF MORPHINE DEPENDENCY INDUCED BY S.C. METHOD ON SPATIAL LEARNING AND MEMORY IN RATS USING MORRIS WATER MAZE

Type: POSTER
Author(s): KARAMI DARABKHANI H.*,POURMOTABED ALI,MEHRABINASAB E.,SORAYA F.,MORADI S.,HAGHIGHIZADEH H.
 
 *DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: In the current study we examined the effect of morphine dependence on spatial learning and memory in male rats using Morris Water Maze (MWM).
Methods: In this study animals received morphine sulfate (10 mg/kg, s.c.) (In both dependent and withdrawal groups) or normal saline (in control group), twice per day (08:00 am & 08:00 pm) for 15 consecutive days. Dependent and control groups from day 11 to 15, but withdrawal animals from day 16 to 20 were studied in MWM. Animals were tested for four consecutive days (4 trials/day) in MWM to evaluate the spatial learning process during which the position of hidden platform was unchanged (training days). On fifth day (probe trial) the platform was removed from maze to evaluate the spatial memory process.
Results: Data showed that differences among escape latencies and travel distances to find platform (in training days) and also differences among percentage of times and distances traveled in target quarter (in probe trial) among studied groups were not statistically significant.
Conclusion: These findings clearly imply that morphine dependence induced by current method has no any significant effect on spatial learning and memory which may result from induction of relative tolerance to morphine in dependent animals.

 
Keyword(s): 
 
 
Yearly Visit 39   tarjomyar
 
Latest on Blog
Enter SID Blog