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Paper Information

Title: 

EVALUATION OF ANTINOCICEPTIVE EFFECT OF GALBANUM BY FORMALIN TEST IN MICE

Type: POSTER
Author(s): KARIMI KHEYRABADI M.,ZARIFKAR A.,EJTEHADI M.,RASTGAR K.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Ferula gummosa Bioss. (Apiaceae) is a perennial plant native to Iran and Afghanistan. Such as many plants this species contain active biological compounds including terpenes. In the current study, analgesic effect of intraperitoneal injection of galbanum (100mg/kg of Ferula exudates) was evaluated by formalin test.
Methods: Thirty male Syrian mice weighing 25-32g in three groups (n=10) were used in this study. Mice were pretreated intraperitoneally (i.p.), 15 minutes before formalin injection, with galbanum (100mg/kg), normal saline and/or DMSO (Dimethyl sulfoxide) as vehicle. Data obtained from formalin test (the pain scores) were analyzed by Tukey test and a p value less than 0.05 were the critical criterion for statistical significance.
Results: the results indicated that pain scores of Galbanum (100mg/kg) administrated mice were significantly less than those of the control mice. The pain scores were reduced in both acute phase P<0.05 and chronic phase in formalin test in mice and it has considerable antinociceptive effect.

 
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