Paper Information

Title: 

PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF MANGIFERA INDICA AND VIMANG AGAINST GENTAMICIN INDUCED NEPHROTOXICITY

Type: POSTER
Author(s): GHAZI L.,BOROUSHAKI M.T.,KHAJAVI A.,KHOUEI A.R.,AYAT ELAHI H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Amongst aminoglycosids, gentamicin (GM) has the extended use in different infectious diseases that causes proximal tubular necrosis, increases urea and creatinine, produces free radicals and decreases creatinine clearance. In this project protective effect of Mangifera indica extract and Vimang were studied.
Methods: Wistar albino rats were randomly divided into 7 groups. Group one received saline, group 2 received gentamicin (100mg/kg) for 8 days, groups 3-4 received Vimang (50 and 100mg/kg), groups 5-6 received extract (200 and 400mg/kg) respectively 10 days before treating with gentamicin. Group 7 received extract (400mg/kg) and group 8 received Vimang (100mg/kg) one hour before gentamicin. Three blood samples were collected from ocular sinus and level of urea and creatinine
were determined.
Results: in group 2, level of urea and creatinine was 85±8 and 1.15
±0.3 mg/dl. Data shown that in all groups, except group 3, level of creatinine, but not urea, was significantly lower than group 2.
Conclusion: vimang and extract of Magnifera indica are able to protect kidneys against gentamicin-induced nephrotoxicity.  

 
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