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Paper Information

Title: 

THE EFFECT OF FIBRONECTIN OF PLASMA ON TREAT, MENT OF DEEP SKIN SURGERIES IN DIABETIC RATS

Type: POSTER
Author(s): POURBAGHER H.,KABIRI N.*,REZVAN S.,ALIZADEH A.A.A.,TAVAN M.
 
 *YOUNG RESEARCHERS CLUB
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Fibronectin was previously been used for treatment on wond bed healing .This study investigates whether topical application of PFn can improve the treatment of wonds bed in diabetic rate or not?
methods: First, we created deep skin wonds on the backs of rats that have been diabetic by STZ (Streptozotoxin) and inject human PFn into wond bed immediately, where as in the two other groups of rats, we use human Albumin serum in one and Normal sialin in the other as an example.Coagulation of injury is the sign of correct use of parameters of injury treatment that are; spreading and contraction of covering surface, becoming veined; to settle of collagen and transferring of fibroblasts in histology experiments. We measure the transformation of growth factor (TGF)-β1 by immuno chemical science. Also, we evaluate Hidroxi peroline layers injury of skin.
Conclusions:The quick coagulation of injury resulting from tropical application of PFn. furthermore; the use of PFn is the sign of increasing of vein Fibroblast, producing of collagen and getting coveredof injury surface.The amount of quick osmosis of fibroblasts of (TGF)-β1 and Hidroxi prolin layers in injuries that receive PFn is more clear than injuries in example rat.End pointPFn can improve the treatment of diabetic injuries and causes in creasing of Fibroblasts activity and gettingfree of (TGF)- β1.

 
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