Paper Information

Title: 

THE EFFECT OF ZINC CHLORIDE OF PREGNANT RATS ON PASSIVE AVOIDANCE MEMORY OF THEIR OFFSPRINGS IN SECOND GENERATION

Type: POSTER
Author(s): GHOTB ALDIN Z.,MOAZEDI A.A.,PARHAM GH.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Zinc is an essential dietary element for many biological processes, modulates neurotransmission in brain region and associated with learning and memory and it is the second most abundant transition element in the body. Apoptosis plays a role in many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease. Zinc is essential for normal central nervous system development and function. Imbalances of this metal, either excess or deficiency, can result in neuronal apoptosis. Because of a deficiency of this nutrient in pregnant animals has been shown to result in, malformations and abnormal development and functioning of the central nervous system of their offspring’s, in this research we evaluate the effect of zinc supplementation of pregnant rats on passive avoidance memory of their offspring’s in second generation. In this work pregnant rats received a daily oral dose of 30mg/kg Zn as zinc chloride for two weeks by gavage. A shuttle box used to test passive avoidance memory of their offspring’s in second generation. Two criteria were considered to behavioral test, including latency in entering dark chamber and time spent in the dark chamber. This experiment showed that oral administration of zncl2 (30mg/kg/day) after 2 weeks at the stage of pregnancy, can improve passive avoidance memory of their offspring’s in second generation (p<0.05). It seems zinc modulated NMDA receptor and poly-ADP-ribose-polymerase І, which participate in memory formation.

 
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