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Paper Information

Title: 

STUDY ON THE POSSIBLE ROLE OF INTEGRINS IN DEVELOPMENT OF TOLERANCE TO THE ANALGESIC EFFECT OF MORPHINE IN MALE RATS

Type: POSTER
Author(s): GHORBI J.,SATARIAN L.,JAVAN M.,SHEYBANI VAHID
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: There is evidence that the function of integrins varies following chronic administration of morphine. These variations might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes it to be activated. On this study, attempt has been made to investigate the effect of activating integrins using manganese on tolerance development to the analgesic effect of morphine.
Methods: To induce tolerance to analgesic effect of morphine, morphine (15µg) was injected intrathecally to male rats twice a day for five days. To investigate the effect of manganese (20nmol/rat), it was injected intrathecally just 15 minutes before morphine injections during mentioned period. The analgesic effect of morphine (15µg/rat) was measured using tail flick test on day 6.
Results: The results indicated that in animals which received both manganese and morphine during first 5 days, morphine induced a significant analgesia on day 6. Chronic administration of manganese did not have any effect on the pain threshold. Comparison of the tail flick latencies on day 6 for manganese treated animals and animal treated with the combination of manganese and morphine, indicated that manganese did not have any effect on the morphine analgesia.
Conclusion: Our results showed that, manganese administration prior to morphine prevents morphine tolerance development. It seems that the modulation of integrins activity following chronic administration of morphine and probably their reduced activity, play a role in tolerance development to morphine analgesia. Further investigation needs to be carried out to determine whether manganese effect is dependent upon the integrins role in cell adhesions, or upon their intracellular signaling pathways.

 
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