Paper Information

Title: 

THE EFFECT OF TRAMADOL IN MEMORY CONSOLIDATION IN MICE

Type: POSTER
Author(s): GHAROUEI S.,GHARGHABI F.,ZAKER ABBASIAN M.,MOGHADAMNIA A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Tramadol mixed actions on opioid, central adrenergic and serotonergic systems can represent analgesic effect. Some studies suggested that tramadol can exert behavioral effects. In this study, the possibly effect of tramadol on learning consolidation in mice was investigated.
Methods: The mice were divided into four groups in two shock durations: saline 10ml/kg, tramadol 12.5 mg/kg, tramadol 25 mg/kg and tramadol 50 mg/kg. Step-through passive avoidance learning method was recruited. The mice were trained with two different shocks (duration: 4 and 8 second, 0.1mA). All drugs were immediately injected (i.p.) after giving shock. The mice were trained with three different shock periods (duration: 2, 4 and 8 second, 0.1mA). Recall test was done 1hr, 24 hr and one week after training and cut-off time was considered maximum 300 seconds
.
Results: In comparison to saline (with exception after 24 hr in shock duration 4 second for saline), tramadol in all doses showed an improvement in recall in the mice. The most predominant effect of tramadol was observed with tramadol 50mg/kg after 24 hr recall test (p=0.016). In shock duration 8 second, saline only showed better recall after one week and for all tramadol doses better recall was seen
.
Conclusion: According to the data, it seems that tramadol can increased the depth learning consolidation in mice. It is suggested that the different shock intensities can not induce various effect on recall duration.

 
Keyword(s): 
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog