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Paper Information

Title: 

GLUCOCORTICOIDS MODULATE ALLODYNIA AND HPERALGEISA IN RAT MODEL OF NATUROPATHIC PAIN

Type: POSTER
Author(s): FARYADIAN S.,SAFAKHAH H.A.,RASHIDIPOUR A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Damage to peripheral nervous system induces chronic neuropathic pain. Since levels of glucocorticoids and also expression of their receptors have been demonstrated to change during neuropathic pain, this study examined the effects of corticosterone on neuropathic pain like behaviors (allodynia and hyperalgesia) induced by chronic constriction nerve injury (CCI) in rats.
Methods: Adult male Wistar rats (250-300gr) were used in this study. CCI rats were produced by loosely ligating common sciatic nerve according to procedures described elsewhere (Bennett & Zie 1988). Experimental groups were: control, sham and CCI. Behavioral studies were performed two weeks after CCI using standard tests. The measured neuropathic like pain behaviors were: mechanical and thermal allodynia, and thermal hyperalgeisa. Corticosterone (CORT) at doses of 5 and 10 mg/kg were injected 45 min before behavioral tests.
Results: The results indicated that: 1) behavioral responses (allodynia and hyperalgesia) were significantly increased in CCI rats in comparison with sham ones. 2) CORT at dose of 5mg/kg only increased thermal hyperalgesia, but at dose of 10mg/kg, it enhanced all behavioral responses.
Conclusion: The data indicate that glucocorticoids can diminish neuropathic pain like behaviors and suggest a potential role for glucocorticoids in the treatment of neuropathic pain.

 
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