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Paper Information

Title: 

EFFECT OF NUCLEUS BASALIS OF MEYNERT STIMULATION ON RESPONSE PROPERTIES OF RAT BARREL CORTEX NEURONS

Type: POSTER
Author(s): GOSHDAROU F.*
 
 *DEPT OF PHYSIOLOGY, PARAMEDICAL FACULTY, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The nucleus basalis of Meynert (NBM) contains a population of large cholinergic neurons that send their axons to widespread areas of the cortex and provide the major cholinergic inputs to the cerebral cortex. In this study, the effect of NBM stimulation on response properties of rat barrel cortex neurons was examined. The primary somatosensory cortex representing face contains aggregations of neurons in layer IV called "barrel", each corresponding to individual whiskers on the contra lateral face.
Methods: Extra cellular single-unit recording to computer-controlled displacement of whiskers were obtained in layer V of barrel cortex of wistar male rats. NBM was electrically stimulated and response properties of neurons in barrel cortex before and after NBM stimulation were compared.
Results: The results show that NBM electrical stimulation changed evoked responses in 60.7% of neurons. The others (39.3%) were not affected. The decreasing responses after NBM stimulation were the most observed effect. This effect was eliminated in 800ms. NBM simulation significantly decreased response latency, while it did not change the spontaneous activity of neurons.
Conclusion: It was concluded that NBM has an important role in regulating the balance of excitation and inhibition in the barrel cortex.

 
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