Paper Information

Title:  EFFECT OF CHAMMAEMELUM NOBILE AQUEOUS EXTRACT ON FORMALIN INDUCED PAIN AND INFLAMMATION IN MICE
Type: POSTER
Author(s): GOLABI M.,KHAYAT NOURI M.H.,REYHANI B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Herbal medicine have been used herbs for treatment of pain and inflammatory since long times ago. It have been shown that the extract of Chamaemelum nobile possess sedative, antinociceptive, and anti-inflammatory activities. The aim of this study was investigating the effect of Chammaemelum nobile aqueous extract on formalin induced pain and inflammatory in mice.
Methods: Animals pretreated with Chammaemelum nobile aqueous extract (0.5 g/kg) orally before intrapadly formalin (20µl, 0.5%) injection. The time of licking and biting of injected paw was measured as pain response at 5 min intervals for an hour.
Results: The results showed that formalin induced a biphased pain response (first phase; 0-5 min & second phase; 15-45 min after injection) and orally administration of Chammaemelum nobile aqueous extract before formalin injection, reduced the second phase of pain response significantly (P<0.05) and it hadn't significant effect on first phase (p≥0.05).
Conclusion: In conclusion our results suggest that the effect of Chammaemelum nobile aqueous extract is probably because of the flavonoid compounds containing of this herb. (flavonoid compounds have antioxidant, antinociceptive and anti inflammatory possession).

 
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