Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

EFFECT OF SEX IN MORPHINE CONDITIONING RESPONSE

Type: POSTER
Author(s): KARIMI M.*
 
 *DEPT. OF BIOLOGY, FACULTY OF BASIC SCIENCES, SHAHED UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: A possible sex-related effect of morphine (0.5-10 mg/kg, s.c.) conditioning response in Wistar rats was investigated as evidence propose a sex difference in morphine reinforcing effect in Sprague-Dawley rats.
Method: Place conditioning in rats induced by using a 3-day schedule of an unbiased procedure. Single doses of naloxone (0.5-2 mg/kg, i.p.) or sulpiride (0.5-2 mg/kg s.c) were also pre-administered through the conditioning procedure, providing evidence to further elucidate the mechanisms governing upon reinforcing properties of opioid in animals.
Results: Present results show that morphine (0.5-10 mg/kg, s.c.) produced a significant place preference in a dose-dependent manner in both sexes of Wistar rats (weighing 200-250g). Female rats conditioned to place at lower doses of morphine (0.5 mg/kg, s.c.). Moreover, the increase in response-induced by morphine at higher doses (5 to 10 mg/kg, s.c.) was more pronounced in females. Administration of morphine at 0.5-10 mg/kg (s.c.) during conditioning, in female but not in male rats showed a significant increase (at 7.5 mg/kg of opioid) in locomotor activity. Morphine also increased the animals' body-weight at higher doses (10 mg/kg, s.c.). The results also demonstrate that naloxone (0.5-2 mg/kg, i.p.) induced a significant place conditioning at higher doses in both sexes with no significant effect on locomotor activity. The drug in males but not in females showed a significant effect on animals' body-weight. Injection of single doses of sulpiride (0.5-2 mg/kg s.c.), through the conditioning, showed a significant aversion at higher doses (1-2 mg/kg, s.c.) in males but not in females with no significant effect on locomotor activity or body-weights. When sulpiride at 0.5-2 mg/kg (s.c.), preinjected to morphine, a higher dose of the antagonist (2 mg/kg, s.c.) in males attenuated the opioid response.
Discussion: These results may highlight sex-related morphine reinforcing and locomotor effects in subjects, and that the Mu-opioid receptor or D2 receptor may play an important role in the reinforcing effects of morphine in Wistar.

 
Keyword(s): 
 
 
Yearly Visit 39   tarjomyar
 
Latest on Blog
Enter SID Blog