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Paper Information

Title: 

EFFECT OF POST-ISCHEMIC TREATMENT OF PENTOXIFYLINE ON CORTICAL AND STRIATAL DAMAGE IN TRANSIENT MODEL OF FOCAL CEREBRAL ISCHEMIA IN RAT

Type: POSTER
Author(s): VAKILI A.,ZAHEDI KHORASANI M.,GHAHRAMANINIA A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Pervious studies reported that Pentoxifylline (PTX) has neuroprotective effect in the brain trauma and the global cerebral ischemia in the experimental models. However, the effect of PTX in transient model of focal cerebral ischemia has not been investigated yet. Therefore, this study was designed to investigate the effect post-ischemic treatment PTX on ischemic injuries in focal cerebral ischemic.
Methods: Male Wistar rats (n=32) were assigned to control or PTX (60 mg/kg ip) treated groups. PTX at dose 60 mg/kg ip administered at the beginning, or one, or three hours after ischemia. Focal cerebral ischemia was induced by middle cerebral artery occlusion, followed by 24-hours reperfusion. At the end of 24 hrs ischemia, neurological dysfunction score was tested and infarct volumes were determined using Triphenyltetrazolium chloride staining.
Results: Administration of PTX (60 mg/kg) at the beginning of ischemia, or one, or three hrs after ischemia significantly reduces cortical infarct volumes by 43%، 40% and 41%, respectively. While, PTX did not significantly affect on striatal infarct volumes and neurological dysfunction.
Conclusion: The findings of present study indicate that administration of PTX at least 3 hrs post transient focal stroke reduces cortical brain ischemic damage in rat model of transient focal cerebral ischemia.

 
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