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Paper Information

Title: 

EFFECTS OF CONCURRENT ADINISTRATION LITHIUM AND GETAMICIN ON THE HISTOEMBRYOGENESIS OF RAT FETUS DURING THE DEVELOPING PERIODS

Type: SPEECH
Author(s): NOORI S.H.,MINAEI ZANGI M.B.,AKBARI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

This study was planned to investigate the effects of gentamicin and littium on rat histoembryogenesis and to determine the effects, if any, of lithium as a potent gentamicin inhibitor. The rats were exposed subcutaneously to 110-mg/kg gentamicin on days 6-15 of gestation. Lithium administered orally at doses 1200mg/l on days 6-15 of gestation. Fetuses were collected on day 21 and compared with those of the untreated, and saline treated control as well as with those of the gentamicin and lithium treated groups. All control and cases embryos groups were killed and their tissues were obtained. Then prepared for paraffin block, sectioning, H-E staining and light microscopic studies, we fond that gentamicin caused growth retardation versus lithium which doesn't did so. Lithium has a state like control but no wary exactly. Furthermore, concurrent administration of gentamicin and lithium caused regularity in histoembryogenesis cycle and the normal growth beside the lithium or gentamicin. Of course the recent result is not exactly comparable to those of controls.

 
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