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Paper Information

Title: 

EFFECTS OF BERBERIS VULGARIS FRUIT EXTRACTS AND ITS ACTIVE COMPONENT, BERBERINE ON MORPHINE DEPENDENCE, HYPNOSIS AND LOCOMOTOR ACTIVITY IN MICE

Type: SPEECH
Author(s): NASIRIASL M.*,HOSSEINZADEH H.
 
 *DEP. OF PHARMACOLOGY, QAZVIN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The effects of aqueous and ethanol extracts of Berberis vulgaris (barberry) fruit, as well as its active constituent, berberine, were studied on morphine dependence, hypnotic potentiation, muscle relaxant and locomotor activity in mice.
Methods: Dependence was induced using by morphine (50, 50, 75 mg/kg, s.c) daily for 3 days. On day 4, morphine was injected before naloxone (5 mg/kg, i.p.). The number of episodes of jumping during 30 min was considered as the intensity of the withdrawal syndrome.
Results: Berberine (10- 20 mg/kg, i.p.) reduced the number of jumping episodes after the dependence significantly. The i.p. injection of aqueous and ethanol extracts of barberry in different doses, decreased the number of jumping episodes significantly during the development of dependence and after dependence. However, the effects during development of dependence appeared only in lower doses. Intraperitoneally administration of aqueous (200-300 mg/kg) and ethanol extracts (100-200 mg/kg), and berberine (10-20 mg/kg) significantly reduced the locomotion of mice. In the potentiation of pentobarbitone sleep test, berberine significantly increased sleeping time and decreased latency at the doses of 5-10mg/kg in mice. Also the aqueous (100mg/kg) and ethanol extracts (100-200mg/kg) of barberry increased sleeping time and decreased latency significantly in mice. In the traction test, berberine and both extracts couldn't show muscle relaxant activity.
Conclusion: The present data support the hypothesis that the extracts of barberry and berberine have some potential role in potentiation inhibitory neural pathway and decreasing morphine dependence, locomotor activity and inducing hypnosis.

 
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