Paper Information

Title: 

FREE LEPTIN IN DIABETIC PATIENTS AND ITS CORRELATION TO INSULIN RESISTANCE

Type: SPEECH
Author(s): MOHITI ARDAKANI J.,TALEBI F.,BABAEI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Leptin is a hormone resulting from the obesity gene. Their actions could be important in the pathogenesis of the Insulin; only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available. We therefore studied the effect of free leptin on blood insulin in diabetic patients.
Methods: Thirty Obese diabetic (age: 50±20 yr & BMI>30 kg/m²) patients and thirty non- obese (age: 50±23 yr & BMI <25 kg/m²) patients were studied. Free leptin was purified by Gel filtration chromatography and the fractions were collected and then their free leptin was measured by a high sensitive ELISA method. Circulation total leptin and insulin was measured by ELISA.
Results: Circulation free and total leptin were significantly higher in obese diabetes compare to non-obese diabetes patients (P<0.05). Free leptin concentrations was higher in women than in men. Statistical analysis of results indicate a direct significant correlation between free leptin with insulin (r=0.39, P=0.002) and total leptin with insulin (r=0.46, P=0.00).
Conclusion: The majority of leptin which circulates in obese individuals was free form. Presumably it is bioactive protein of hormone and thus obese subjects are resistant to free leptin. These observations are consistent with the view that free leptin levels in diabetes patients attributed to changes in serum insulin level and insulin resistant.

 
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