Paper Information

Title: 

THE EFFECT OF SECURIGERA SECURIDACA (L.) (DEGEN & DOERFLER) SEED IN TYPE II DIABETIC PATIENTS; A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

Type: SPEECH
Author(s): FALAH HOSSEINI H.*,HOSSEINI P.,HESHMAT RAMIN,YAZDANI D.,HEMATI MOGHADAM H.R.,RAHMANI M.,ALAVI S.H.R.,ARDESHIR LARIJANI MOHAMMAD BAGHER
 
 *DEPARTMENT OF PHARMACOLOGY, INSTITUTE OF MEDICINAL PLANTS, ACECR, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Securigera securidaca (L.) seeds are used by traditional herbalists for the treatment of diabetes in several parts of Iran. Clinical investigation of its efficacy and its toxicity in diabetic patients is of importance.
Methods: A 2-month randomized double blind clinical trial was conducted in 70 type II diabetic patients in two well-matched groups. One group (n=35) received 500 mg Securigera securidaca (L.) seeds capsule 3 times a day plus standard therapy, while the control group (n=35) received placebo plus standard therapy. The patients were visited monthly and glycosylated hemoglobin (HbA1c), fasting blood glucose, total cholesterol, LDL and HDL, triglyceride, SGOT, SGPT, ALK, BUN, serum creatinine levels were determined at the beginning and the end of the study after two months.
Results: There was no significant change in HbA1c and fasting blood glucose level in Securigera securidaca (L.) seeds treated patients after two months as compared to beginning of the treatment and also as compared to placebo group. Serum lipid level also did not change significantly. The liver enzyme level and creatinine level in blood did not change significantly in Securigera securidaca (L.) seeds treated patients. No side effect was observed in any of patients in both of the groups.
Conclusion: Securigera securidaca (L.) seeds treatment with known antidiabetic property in traditional herbal therapy has no beneficial effect on improving glycemic profile in type II diabetic patients. The use of this herbal medicine in the dose of 1500mg in 3 divided doses showed no gasterointestinal symptom as well as liver and kidney abnormality during two months therapy. The long term efficacy and toxicity of this herbal medicine in higher dosage may be investigated in large multi center clinical study.

 
Keyword(s): 
 
Yearly Visit 10   tarjomyar
 
Latest on Blog
Enter SID Blog