Paper Information

Title: 

EVALUATION OF MDR1 GENE POLYMORPHISM INFLUENCE ON OCCURRENCE OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Type: SPEECH
Author(s): MILADPOUR B.*,NEJAT SHOKOUHI A.,BEHRAVAN J.
 
 *MASHHAD UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The significance of genetic background in acute lymphoblastic leukemia (ALL) is not well understood. Polymorphism of genes encoding xenibiotics and drug transporters are potential factors, which can influence the risk of developing (ALL) and its clinical outcome. P-glycoprotein (P-gp) is an adenosine triphosphate binding cassette (ABC) family transporter involved in protection against xenobiotics and multi drug resistance. Recently, the single nucleotide polymorpism C3435T of MDR1 gene has ben found to be associated with altered tissue expression and function of P-gp.
Methods: To evaluate whether C3435T MDR1 polymorphism is associated with the occurrence of ALL, 130 patients with ALL and 139 healthy individuals of Iranian origin (Khorasan province) where studied by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) assay.
Results: The mutant homozygous TT genotype was found to be associated with occurance of ALL (OR=1.96 CI=1.07-3.58; p-value=0.026) and heterozygous TC genotype was associated with reduced occurance of ALL (OR=0.53 CI=0.32-0.89; p-value=0.017).
Conclusion: In conclusion, the results of the present study provide evidence that C3435T MDR1 polymorphism may be associated with susceptibility to ALL. Carriers of the TT genotype are more at risk of developing ALL than other individuals.

 
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