Paper Information

Title: 

NEUROPROTECTIVE AND CARDIOPROTECTIVE EFFECTS OF ERYTHROPOIETIN IN ACUTE STROKE AND ACUTE MYOCARDIAL INFARCTION

Type: PAPER
Author(s): MOHAMMADPOUR A.H.*,ABEDI H.
 
 *PHARMACODYNAMY AND TOXICOLOGY DEPARTMENT, SCHOOL OF PHARMACY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Erythropoietin (EPO) is a Cytokine produced primarily in kidneys in response to hypoxia, that promotes proliferation and differentiation of erythroid cells and is widely used for the treatment of anemia in patient with Chronic renal failure. EPO-receptors (EPO-R) is detected in the Cardiovascular System, including endothelial cells and cardiomyocytes and in rodent and human brain tissue. From the experimental studies, EPO Seems to influence 2 processes during Cardiac ischemic injury, first by acutely reducing the infarct new vessels formation over a longer time frame. Acute protective effects of erythropoietin are mediated by activation of protein Kinases and potassium channels. A variety of in vivo and in vivo Studies show that erythropoietin Prevents neuronal apoptosis after Cerebral ischemia. The results of clinical trials in this field were evaluated to assess the efficacy of EPO administration in patient with acute MI and acute Stroke. At present two randomized clinical trials in this field is being Carried out in Ghaem hospital Mashad University of Medical Sciences.

 
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