Paper Information

Title: 

EFFECT OF FALCARIA VULGARIS EXTRACT ON ISOLATED RAT HEART

Type: POSTER
Author(s): GOUDINI A.A.*,SHAKIBAEI D.
 
 *MEDICAL BIOLOGY RESEARCH CENTER AND AND DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Cardiovascular effects of herbal medicine have been shown in numerous studies. Falcaria Vulgaris traditionally has been used as an herbal medicine and its Positive effect on peptic ulcer and skin wound has been shown in some studies. There is some evidence about its cardiac effect. In addition special chemical substance called Butylidenephthalide has been extracted from the similar plant can reduce myocardial ischemia in rat. This study is aimed to consider the effect of Falcaria Vulgaris extract on isolated rat heart function.
Methods: Adult male NMRI rats (n=11) were used in this experiment. After anesthesia heart was isolated and perfused in Langendorff method and cardiac function parameters including heart rate (HR), left ventricular developed pressure (LVDP), and coronary solution flow (CSF) were measured and rate pressure product (RPP) was calculated as well. Hydro alcoholic extract of Falcaria Vulgaris leaves was prepared and amounts 7.5, 15, 22.5 and 30 mg were administered to the hearts with ten minute intervals.
Results: Results show 7.5, 15, 22.5 mg increased CSF from 11.52±0.6 ml/min (Mean±SE) to 12.93±0.56, 13.8±0.88 and 13.78±0.85 ml/min respectively (p<0.05). There weren't any significant changes in other parameters (LVDP, HR and RPP).
Conclusion: Therefore this finding shows a coronary vasodilator effect of Falcaria Vulgaris. With regards to this fact that there were not any significant changes in cardiac function parameters, it can be concluded that this is direct effect and is not dependent to metabolism. Hence the complementary study for clarifying of the cellular mechanism of extract is suggested.

 
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