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Paper Information

Title: 

INVESTIGATING THE CALORIC RESTRICTION ON ACE ACTIVITY AND BLOOD PRESSURE IN MALE WISTAR RATS

Type: POSTER
Author(s): SHARIFI A.M.,ORYAN SHAHRBANOU,MOHSENI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Overweight is one of the most worldwide cues particularly in industrial and developed countries. Obese subjects are at high risk for developing various disorders such as diabetes and especially cardiovascular disease. It has been well established that life style modification plays an important role in reducing these problems, particularly weight reduction and carloric restriction (CR) as a non-pharmacological approach. In the present study the possible effect of caloric restriction on ACE activity and blood pressure in rat were investigated.
Methods: Two groups of rats were selected as control and CR subjects, fed with standard pellet, and an every other day diet respectively for 4 weeks. The systolic blood pressure (SBP) was measured in all groups using the tail-cuff method under light general anesthesia induced by ether. Angiotensin Converting enzyme (ACE) activity were determined in serum and tissue using HPLC method.
Results: In CR experimental SBP was significantly decreased (p<0.001), serum ACE activity was decreased (p<0.05), Aortic, heart, kidney and lung ACE activity were decreased (p<0.01) compared to controls.
Conclusion: On the basis of result, it could be concluded that Caloric restriction may reduce blood pressure via decreasing serum and tissue ACE activity.

 
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