Paper Information

Title: 

EFFECT OF AMLODIPINE ON CAROTID TISSUE CONCENTRATION OF ENDOTHELIN IN RABBITS RECEIVING ATHEROGENIC DIET

Type: POSTER
Author(s): MOHAMMADI M.*,MIRZAEI F.,ASLANABADI N.
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Endothelin-1 is involved in inducing and progressing of atherosclerosis since in atherosclerotic vessels obvious and certain changes with abnormality in transferring of calcium ions are seen, calcium channel blockers can slowdown the process of atherosclerosis.
Methods: 36 male Newsland white rabbits were divided into four groups: The normal control group, normal group receiving amlodipine, high-cholesterol diet group and high-cholesterol diet with amlodipine group.
Results: In plasma endothelin-1 level results indicate that difference among groups of amlodipine, high-cholesterol diet and high-cholesterol diet plus amlodipine compared with control group is significant (p=0.000) In tissue level of endothelin in carotid artery, groups of high-cholesterol diet and high-cholesterol diet plus amlodipine have significant difference (p=0.000).
Conclusion: The tissue endothelin level of carotid artery was increased in high-cholesterol diet. In situation with high-cholesterol diet plus amlodipine the endothlin level was decreased.

 
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