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Paper Information

Title: 

THE EFFECTS OF SHORT-TERM APPLICATION OF NATURAL HONEY ON ISCHEMIA-INDUCED VENTRICULAR ARRHYTHMIAS IN ISOLATED HEARTS

Type: POSTER
Author(s): MAHDIZADEH AGHDAM E.,NAJAFI M.,RAFI F.,ETERAF OSKOUEI T.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In this study, effects of short-term application of natural honey on ischemia-induced ventricular arrhythmias were investigated in isolated rat hearts.
Methods: Isolated rat hearts were divided into three groups (n=8 in each group) and mounted on a Langendorff apparatus at constant pressure. In the control group, the hearts were perfused by a modified Krebs-Henseleit solution during stabilization and 30min regional ischemia while in the test groups, they were perfused by enriched Krebs solution with natural honey (0.5 and 1%) 10min before to 10min after ischemia. Then the ischemia-induced ventricular arrhythmias were analyzed based on the Lambeth conventions.
Results: The total number of ventricular ectopic beats (VEBs) in the control group was 667±116, however, perfusion of natural honey (0.5 and 1%) reduced it to 180±48 (p<0.01) and 303±94 (p<0.05), respectively. The number of ischemic ventricular tachycardia (VT) was also lowered by the same concentrations from 280±50 (control) to 7±4 (p<0.01) and 40±13 (p<0.01), respectively. The control group spent 58±19sec in VT but the time was reduced by honey (0.5% and 1%) to 2±1sec (p<0.01) and 11±4sec (p<0.05), respectively. At the same time, honey (0.5%) decreased the incidence of VT from 100% in the control group to 40% (p<0.01). Despite a reduction in the incidence and time spent for reversible ventricular fibrillation (VF) by honey, the effect was not statistically significant.
Conclusion: This study showed a protective role for natural honey against ischemic injuries as a clear antiarrhythmic effect. It seems this effect is probably related to the presence of antioxidant compounds.

 
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