Paper Information

Title: 

THE EFFECT OF LITHIUM ON ISCHEMIC PRECONDITIONING (IPC) IN ISOLATED RAT HEART

Type: POSTER
Author(s): MIRERSHADI F.*,FAGHIHI M.,DEHPOUR A.R.
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

schemic Preconditioning (IPC) is the phenomen that occurred on the heart by one or several brief period of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Such preconditioning effects can be stimulated by pretreating the hearts with pharmacological drugs. Lithium (Li) is one of the most effective drugs for the treatment of bipolar disorder. The present study was carried out to examine the preconditioning effect of acute lithium administration on ischemic reperfused heart. In this examine we used Longendorff setup and the aorta was connulated and the heart was retrogradely perfused in situ avoid ischemia. Ischemia was achieved by clamping the aortic perfusion catheter in such as way that coronary flow was reduced to zero. First the effect of IPC phenomen with 5 minute ischemia followed 5 minute reperfusion before 30 minute hschemia, is examined then the heart were perfused with 0.5, 1, 3 and 5mmol lithium for 10 minute before 30 minute global ischemia. IPC improve the postischemic recovery and 3mmol of lithium is the best dosage that reduced postischemic ventricular dysfunction in heart as well as reduction of infarct size.

 
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