Paper Information

Title: 

STUDY OF THE EFFECTS OF L-CARNITINE ON HEMODYNAMIC FACTORS IN ISCHEMIC ISOLATED RAT HEARTS

Type: POSTER
Author(s): GHARAHKHANI A.,NAJAFI M.,GARJANI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Some controversial data do not permit definitive conclusion yet about the efficacy of L-carnitine (L-CAR) on hemodynamic function in ischemic heart. In this study, the effects of L-CAR perfused during 10min before and 10min after ischemia on hemodynamic factors including left ventricular end diastolic pressure (LVEDP), left ventricular developed pressure (LVDP), heart rate (HR), rate pressure product (RPP) and coronary flow rate (CFR) were investigated.
Methods: Isolated hearts of male SD rats were divided into 4 groups (n=6 in each group) randomly and perfused with carbogenated Krebs-Henseleit solution after mounting on a langendroff apparatus under constant pressure. Normal Krebs-Henseleit was perfused during stabilization and 30min regional ischemia in control group but in the test groups, they were perfused with 0.5, 2.5 and 5mM of carnitine-enriched Krebs-Henseleit solution during 30min ischemia. HR was recorded by ECG leads and other hemodynamic factors were measured by a latex balloon inserted into the left ventricle. CFR was measured by a time collection of the coronary perfusate that dripped from the heart.
Results: Perfusion of 2.5, 0.5 and 5mM of carnitine-enriched Krebs-Henseleit solution had no significant effect on LVEDP in comparison with the stabilization values. LVDP significantly decreased during 5, 15 and 30 min ischemia (P>0.05) however the effect showed lower extent compared to control. Short-term application of L-CAR during ischemia inhibited greater reduction of HR, RPP and CFR in comparison with the control group.
Conclusion: The results showed that L-CAR protected isolated rat hearts against ischemic injuries as a reduction of LVEDP and improvement of LVDP, RPP and CFR.

 
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