Paper Information

Title: 

EVALUATION THE EFFECT OF THE HYDROALCHOLIC EXTRACT OF CITRULLUS COLOCYNTHIS IN NORMOGLYCEMIC AND STREPTOZOTOCININDUCED DIABETIC RATS

Type: POSTER
Author(s): NIKBAKHT M.R.,GHIASI I.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: The purpose of this study was to evaluate the hypoglycemic effect of hydroalcholic extract of Citrullus colocynthis fruit in normoglycemic and streptozocine induced diabetic rats.
Methods: 45 male wistar rats weighing (250-300gr) have been selected and randomly divided in seven groups. group 1 without any drugs usage, group 2 that received normal saline (IV) and distillation water (oral), group 3 that only receipted streotozotocine (IV), group4 that received extract (1000mg/kg) only, groups5,6,7 that after injection of STZ and induction of diabetes gavaged by 500, 1000 and 1500mg/kg of citrullus colocynthis extract. Diabetes was induced by intravenous injection (45mg/kg) of STZ the the blood sampling was provided directly from animal heart and blood sugar was measured.
Results: the average of normal blood sugar in control group is 156.5±15.7mg/dl and defined as natural blood sugar. The extract in dosage of 500mg/kg reduced the blood sugar not significantly but is dosage of 1000 and 1500mg/kg significantly decreased the blood sugar in a dose-dependent manner (p<0/05). These results also showed that the extract in dosage of 1000mg/kg did not have significant effect on normoglycemic animals.
Conclusion: the results of this study are indicating that Citrullus colocynthis fruit extract dose-dependently reduced the blood glucose level in streptozotocine-induced diabetic rats but did not have significant effect on normal blood sugar.

 
Keyword(s): 
 
Yearly Visit 8   tarjomyar
 
Latest on Blog
Enter SID Blog