Paper Information

Title: 

ROLE OF GUT HORMONE IN APPETITE CONTROL FOLLOWING CORONARY ARTERY BYPASS GRAFTING

Type: POSTER
Author(s): NEMATI M.,BRYNES A.E.,HORNICK P.I.,BRETT S.J.,FROST G.S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Rationale: Hormones released from the gut have been reported to affect appetite (Wren et al. 2001) and may play a role in the altered food consumption of patients (Nematy et al. 2006). The role of peptide ghrelin in nutritional recovery after non-gastrointestinal major surgery is unknown. We used coronary artery bypass grafting (CABG) as an example of anticipated good recovery post major surgery.
Methods: Seventeen patients undergoing CABG {mean (SEM): 70.1 (2.2) yrs, body mass index (BMI) 29.1 (1.4) kg/m2, 15 male} underwent fasting and postprandial (45mins after standard test breakfast) blood sampling pre-operatively (day 0), post-operatively (day 6) and at follow up (day 40). Changes in food intake, biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to 17 matched healthy controls {70.6 (2.3) yrs, BMI 28.4 (1.3) kg/m2}. Data from CABG patients was compared to controls using ANOVA.
Results: we observed an increased post-operative fasting ghrelin compared with pre-operatively (p<0.05). Exaggerated postprandial suppression of ghrelin postoperatively (p<0.05) was accompanied with a 50% reduction in food intake {post-op.4.5 (0.5) MJ/D vs requirements 9.9 (0.5) MJ/D p<0.001), leading to a 4% weight loss and a 5% reduction in muscle arm circumference loss over length of follow up.
Conclusions: Our data support the hypothesis that prolonged changes in fasting and postprandial plasma ghrelin concentrations are associated with impaired nutritional recovery after CABG. These findings are likely to be applicable to similar patient groups undergoing major surgery.

 
Keyword(s): 
 
Yearly Visit 7   tarjomyar
 
Latest on Blog
Enter SID Blog