Paper Information

Title: 

THE EFFECT OF DIAZINON ON FEMALE CHALCALBURUS CHALCOIDES BLOOD ESTRADIOL

Type: POSTER
Author(s): MALEK HOSSEINI M.,JAMILI SHAHLA,MASHINCHIAN MORADI A.,BEHZADI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Diazinon is an organophosphorus pesticide that is extensively used as pesticide in agriculture and households. Eventually it enters the aquatic environment in large quantities and affected wildlife. The effects of Diazinon on blood estradiol level of Female Chalcalburus chalcoides fish were studied.
Methods: Five treatments aquaria with ten fishes in each aquarium were studied: 1 (control), 2 (10μg l-1 Diazinon), 3 (20μg l-1 Diazinon), 4 (40μg l-1 Diazinon) and 5 (60μg l-1 Diazinon).Survival test Showed in 60μg l-1 Diazinon had no mortalitye, so 10-60μg l-1 Diazinon concentrations detected as sublethal dose. Each treatment was repeated for 24h, 48h, 72h, 96h and 168h (1week).After exposure, estradiol level in the blood was measured by RIA (Radio Immuno-Assay).
Results: Results showed that blood serum estradiol levels were highest in the control group and for all fish exposured by diazinon, means of blood estradiol among 4 different treatments during different exposure period were less than control. There was significant change in the blood estradiol level in different exposure period (P<0.05). In this study it is clear that using a sublethal dose of diazinon (60μg l-1) affected the estradiol levels of blood serum in Chalcalburnus chalcoides.
Conclusion: It is seemed that diazinon is indirectly reduced blood serum estradiol level by inhibition of acetylcholinesterase (AchE). Hormone levels have an effect on the integral hypothalamic-pituitary-gonadal axis. This axis is reliant upon a feedback system from estrogen.

 
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