Paper Information

Title: 

EFFECT OF ALCOHOLIC EXTRACT OF PHOENIX DACTYLIFERA SPATHE ON CONCENTRATION OF LH, FSH AND TESTOSTERONE IN ADULT MALE RATS

Type: POSTER
Author(s): MOKHTARI M.,SHARIFI S.,MOGHADAMNIA D.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In the present research the effect of phoenix dactylifera spathe on concentration of LH, FSH and testosterone were studied.
Methods: In this study, 50 male Wister rats, each weighing 282±110g were used. These animals were divided into five groups of tens: the control group receiving normal food, the sham group receiving solvent (distilled water), and three experimental groups receiving 0.05, 0.1, and 0.2 g/kg extract of spathe respectively. The dosages of distilled water and extracts were injected intra peritoneally for 14 days. Eight hours after receiving last doses blood samples were taken and serum concentration of lutein hormone (LH), follico stimulation hormone (FSH) and testosterone were measured by RIA method. The results were evaluated by SPSS and Tukey test.
Results: Statistical analysis of the results indicates that concentration of testosterone decreases significantly in experimental groups receiving 0.05 and 0.1 g/Kg extract, while serum concentration of LH and FSH did not show any significant difference (π≤0.05) among various groups.
Conclusion: According to the results alcoholic extract of phoenix dactylifera spathe reduces serum testosterone and protein synthesis. In addition, the presence of phytosterols in the extract which inhibit 5-a-reductase and aromatase enzymes activities may diminish tissues sensitivity to androgens. Finally, the reduction of sperms in somniferous tubules may due to the estrogenic activities of phytosterols and coumarin.

 
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