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Paper Information

Title: 

THE EFFECTS OF SERUM LEVELS OF THYROID HORMONES ON THE SUSCEPTIBILITY TO HERPES SIMPLES VIRUS (HSV) INFECTION IN THE RAT

Type: POSTER
Author(s): FEYZI H.*,MOATARI A.,VAREDI M.
 
 *DEPARTMENT OF PHYSIOLOGY AND VIROLOGY, SCHOOL OF MEDICINE, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

It has been accepted that most of the well known effects of thyroid hormones (THs) are mediated by their genomic actions. In recent years, nongenomic actions of THs have also been reported. These actions seem to be mediated by hormone binding to the proposed cell surface receptors and modulating the activities of the effectors molecules involved in MAPK, PKC, and PKA signaling pathways. One of these nongenomic actions of THs is the recently discovered in vitro potentiation of antiviral activity of interferons which seems to be mediated mainly by thyroxin. Up to date, this action has not been studied in any in vivo system. In this study, for the first time, we have shown that an elevation in serum levels of THs in the adult male rats significantly (1000 Folds) decreases the susceptibility of these animals to Herpes Simplex Virus infection. In contrast, a reduction in the serum levels of THs significantly (10 Folds) increases the susceptibility of these animals to this infection.
Conclusion: These results indicate that THs can play an important role in regulating the immune responses of the body to viral infection. Moreover, from clinical point of view, one may be able to treat or prevent viral infections by inducing transient alterations in the levels of THs in the body.

 
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