Paper Information

Title: 

THE EFFECT OF PARENTAL MORPHINE ADDICTION ON PITUITARY GONADAL HORMONES IN RAT OFFSPRINGS

Type: POSTER
Author(s): ASAEI R.,PAZHOUHI N.,SHIRKHANI Y.,ZAHEDIASL S.,TARAHI M.J.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Opiates such as morphine administration, decrease serum level of pituitary-gonadal axis hormones in both sexes. On the other hand, morphine can be transferred from mother to offspring via placenta and the maternal milk supply. Thus maternal exposure to morphine during pregnancy may affect serum level of pituitary-gonadal axis hormones in offspring’s too. Focused on the singular role of the pregnant female in the health of the fetus and neonate has tended to minimize concern for possible male mediated effects.
Methods: In this experimental study 40 female and 16 male rats (120-140 days old). Were addicted by oral administration of incremental dose of morphine in drinking water for 21 days. Then male rats were placed with females in 6 forms: 1- male addict = test 2-female addict = test 2 3- male and female addict= test 3 and sham1, shame 2, control group. In puberty offspring’s blood sampling were collected and pituitary-gonadal axis hormones were measured. Data were subjected to student t- test.
Results: In female Offspring’s of test 1 LH (0.086±0.04Iu/L), 17β estradiol (93.2±5.92ng/l) and progesterone (22.46±2.98ng/l) have reduced. But no pituitary-gonodal axis hormones alteration occurred in male offspring’s of this group and offspring’s of test 2 group. There was no pregnancy in test 3 group.
Conclusion: The results suggest that maternal morphine addiction may cause infertility in female offspring’s through pituitary-gonodal axis hormones reduction. So the side effects of maternal morphine addiction in offspring must be considered.

 
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