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Paper Information

Title: 

STUDY OF PHARMACOKINETIC INTERACTIONS OF VITAMIN C AND PHENYTOIN IN RATS

Type: POSTER
Author(s): MINAEIAN M.,GHAFGHAZI T.,MAJDZADEH ARDAKANI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Phenytoin is one of the most important anti-epileptic drugs with mild sedative effects. There is great interest for researchers and therapists to study the interactions of phenytoin with other drugs or foods because of its enzyme inducing effects and specific physicochemical and solubility properties. There are reports indicating vitamin C can affect anti-seizure properties of phenytoin. It is also used commonly in clinic as supplement and can alter the pH of sites for absorption and/or elimination of drug, so we decided to carry out the present study. Male Wistar rats weighted 200-225 g were randomly divided to 8 groups of 6-8. In groups 1 to 4, phenytoin was administered p.o. (30 mg/kg) for a week. In groups 1 to 3, two hours later, saline (5ml/kg), and vitamin C (200, 500 mg/kg) were given respectively. In group 4, animals were treated with vitamin C (500 mg/kg) one hour before phenytoin administration. In groups 5 and 6, phenytoin was administered p.o. (60 mg/kg) whereas normal saline and vitamin C (500mg/kg) were administered i.p respectively. In groups 7 and 8, phenytoin (60 mg/kg) was administered i.p. and other treatments were made similar to before mentioned two groups. Blood samples were taken at 0, 1, 2, 3, 4, 6, 8, and 12 hours after phenytoin administration. Plasma samples were analyzed through HPLC method. Results indicated that main kinetic parameters including AUC 0-∞, AUC 0-t, Cmax, Tmax, and T1/2 didn't change significantly in test groups comparing to the respected controls. Tmax and T1/2 were only parameters, which showed a significant increase in group 4 compared to control group. Results suggested that vitamin C ingestion prior to phenytoin intake results in a delay in phenytoin absorption and/or elimination. Acidic change in gut lumen may explain this interaction however, net results indicating that vitamin C, after chronic or acute administration and with low or high doses has no significant interaction with phenytoin.

 
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