Paper Information

Title: 

THE EFFECT OF ERYTHROMYCIN AND CHICHORY LEAF'S EXTRACT, ON BILE SECRETION OF MICE

Type: POSTER
Author(s): MOEZI N.,NAJAFZADEH H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: This study is about comparison the effect erythromycin and hydroalcoholic extract chichory leaf, on mice bile secretion.
Method: The mice were divided to 6 groups (6 mice in each group). In group 1, after 24 hour fasting, normal saline injected to mice and after 1 hour, animals was sacrificed by ether. Gall bladder was exposed and removed for calculating the bile weight with sensitive scale. In groups 2 and 3, erythromycin (100 and 200 mg/kg) was administered by a bolus ip injection after 24 hour fasting. Evaluation was the same as the group 1. But in groups 4 and 5, erythromycin (100mg/kg/day) was administered for 5 days, and chichory extract was administered (400mg/kg) simultaneously in group number 5. In the 6th group, mice were injected only with chichory extract.
Results: comparison of the calculated weights of all 6 groups showed that: one dose bolus injection of erythromycin (groups 2 & 3) can increase the bile secretion but erythromycin administration continual for 5 days (group nom. 4) can decrease the bile secretion. Groups 5 and 6 (administration of the Erythromycin with chichory extract and chichory extract alone) was showed the same results.
Conclusion: Erythromycin and chichory extract can decrease the bile production.

 
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