Paper Information

Title: 

THE EFFECT OF BROMOCRIPTINE ON BASAL AND HISTAMINE-STIMULATED GASTRIC ACID SECRETION IN ANESTHETIZED RATS

Type: POSTER
Author(s): GHANBARI A.,ELIASI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The protective and antisecretory effects of dopamine agonists on the stomach have been already reported, but effect of bromocriptine (D2 dopamine agonist) on histamine stimulated gastric acid secretion (GAS) is unknown.
Methods: For all gastric sampling, animals were anesthetized and a polyethylen tube was introduced into the stomach through esophagus and a cannula was inserted into the pyloroduodenal junction and passed up into the stomach.
Results: Our data showed that administration of bromocriptine (2mg/kg), 60 minutes before histamine infusion, did not affect basal acid secretion but significantly reduced histamine-induced GAS (P<0.01). Also simultaneously application of bromocriptine and histamine-infusion (0.8 mg/100g/h) had no effect on histamine-stimulated gastric acid secretion. The inhibitory effect of bromocriptine on GAS did not alter by sulpiride (25, 100mg/kg), a D2 dopamine antagonist.
Conclusion: Based on our data, we concluded that reducing effect of bromocriptine (2mg/kg) on histamine stimulated acid output probably mediated by non dopaminergic receptors or unknown subtypes of D2 receptors which are not sensitive to sulpiride.

 
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