Paper Information

Title: 

THE ROLE OF D2-LIKE DOPAMINE RECEPTORS (D4 RECEPTORS) ON PENTAGASTRINE-INDUCED GASTRIC ACID SECRETION IN MALE RATS

Type: POSTER
Author(s): FAHANIK BABAEI J.,ELIASI A.,GHASEMI T.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Dopamine and its agonists have protective and antisecretory effects on stomach and as a whole gastrointestinal function. But there are a few evidences about the role of D2-like (D4 receptors) receptors on gastric acid secretion (GAS). The aim of this study was to consider the effect of D2-like dopamine receptors (D4 receptors) on stimulated gastric acid secretion.
Methods For all gastric sampling, animals (Wistar) were anesthetized and a cannula was inserted into the pylorododenal junction and passed up into the stomach. After washing, the stomach was perfused with physiological saline and perfusate was titrated with NaOH 0.01 N to PH 7.0 every ten minutes.
Results: Intravenous (jugular vein) infusion of pentagastrine (4μg/100g/h) induced marked increased in GAS with a peak response that started from 20th min up to the end of experiment. Gastric acid secretion in control group was 12.6±0.3mEq/10min which was decreased to 5.8±1.3 and 8.3±1mEq/10min by quinpirole 0.1 and 0.05 mg/kg, respectively. Neither up injection of quinpirole (0.01 mg/kg) nor clozapine (D4 antagonist, 10 mg/kg) had effect on stimulated GAS. But clozapine completely blocked the inhibitory effect of quinpirole 0.1mg/kg (8±0.4mEq/10 min in quinpirole group; 17.8±0.5mEq/10 min in clozapine group).
Discussion: Our observations suggest that the D2 like dopamine receptors (D4 receptors) have an inhibitory action on stimulated-gastric acid secretion.

 
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