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Paper Information

Title: 

ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM

Type: POSTER
Author(s): GHARIB NASERI MOHAMMAD KAZEM,YAHYAVI H.,ARABIAN M.*
 
 *DEPT. OF PHYSIOLOGY, AHWAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHWAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Onion (Allium cepa) from Liliaceae has antioxidant and antihypertensive activities. The aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility.
Methods: Onion peel powder was extracted by maceration in 70% alcohol for 72 h. A terminal portion of male rat ileum was dissected and its contractions were recorded isotonically in an organ bath containing Tyrode solution (37 ؛C) under 1g tension.
Results: Extract cumulative concentrations (0.1, 0.2, 0.4 mg/ml) reduced the ileum contraction induced by KCl (60 mM) and by carbachol (10μM) dose-dependently (P<0.0001). The antispasmodic effect of extract was not reduced by tissue incubation with propranolol (1μM), naloxone (1μM), L-NAME (100μM), glibenclamide (10μM) and neither by tetraethylammonium (1mM). In Ca2+-free with high K+ (60mM) Tyrode solution, extract reduced the ileum contractions induced by CaCl2 dose-dependently (P<0.05).
Conclusion: Onion peel extract inhibits ileum contractions without involving β-adrenoceptors, opioid receptors, NO synthesis, and without potassium channels activation. It seems that the voltage dependent calcium channels are involved in the spasmolytic effect of the extract.

 
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