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Paper Information

Title: 

EFFECT ON DIABETES MELLITUS ON GASTRIC MOTILITY RAT (IN VITRO STUDY)

Type: POSTER
Author(s): NABAVIZADEH F.,ADELI S.*
 
 *DEPARTMENT OF PHYSIOLOGY, TEHRAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Diabetic patients have abdominal pain, vomiting and bloating. Gastric emptying is delayed in diabetics. There are not any research about gastric motility (gastric contractility) in diabetic patients. Our purpose of this study is to determine the effects of STZ-induced diabetes on basal and stimulated by Ach on gastric contractility in rats. We choose 250-350gr weighted male wistar rats. The diabetic rats received STZ (45mg/kg, IP), vehicle group received normal saline and control group received nothing. Sample blood was collected every week up five weeks for blood sugar measuring. Blood sugar more than 300mg/dl was as criterion diabetes. After day 35, the animals were anesthetized by nesdonal (50mg/kg, IP). Laparatomy was done and a circle was cut from gastric fundus and put in tissue bath in oxygenated crebs solution and physiograph by special thread and Ach-stimulated situation .Basal contraction force of gastric fundus for control, vehicle and diabetic groups were 1.49+0.5, 1.78+0.33 and 1.25+0.3gr tension/mg tissue, respectively Ach-stimulated contraction force for control, vehicle and diabetic groups were5.7+0.64, 5.17+0.64 and 4.31+0.51gr tension/mg tissue, respectively. There were no differences in the basal and stimulated contraction force between three groups. But Ach- stimulated contraction force was more than basal states in every group therefore diabetes had no change gastric motility (contraction force. Although, before study could change gastric secretion in shorter period. We recommend more studies to clarify this research.

 
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