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Paper Information

Title: 

STEREOLOGICAL CHANGES OF VOLUMETRIC PARAMETER OF CEREBRUM IN MALE ADULT RAT FOLLOWING LITHIUM ADMINISTRATION

Type: SPEECH
Author(s): MAHMOUDZADEH SAGHEB H.R.,HEIDARI Z.,NOURI MOUGEHI S.M.H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

Lithium is the lightest alkali metal, which has many industrial and medical uses. These include cluster and migraine headaches, mood disorder, schizophrenia and it also is important in treatment of bipolar disorder. In this study, effects of Lithium on volumetric parameters of cerebrum were investigated by using stereological methods. 20 sexually mature Wistar male rats (Age: 60 – 70 days old) were selected and divided in two groups randomly (n=10). Administration and control groups received 0.1 percent Lithium sulfate solution and distilled water respectively as drinking water during a period of 8 weeks continuously. Then rats were anaesthetized and their cerebrum excised and fixed in modified Lillie’s solution. Then tissue blocking in 4% agar was done. Blocks were sectioned to 1-millimeter thick sections by using a tissue slicer then a grid of standard points was thrown randomly on the slices and after counting of crossing point between grid and objects volume of gray matter, white matter and total cerebrum was estimated by using Cavalieri principle. Data analyzed by nonparametric statistical test of Mann Whitney, and differences between groups less than 0.05 considered significant. Results showed that there were no significant difference in terms of total volume and gray matter and white matter volume of cerebrum between administration and control groups (P>0.05).It was concluded that Lithium 0.1% might not affect cerebral volumetric parameters in rats.

 
Keyword(s): LITHIUM, STEREOLOGY, CEREBRUM, RAT
 
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