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Paper Information

Title: 

THE ROLE OF NITRIC OXIDE ON SPASMOLYTIC EFFECT OF RUTA CHALEPENSIS LEAF HYDROALCOHOLIC EXTRACT ON THE MALE RATS ILEUM

Type: POSTER
Author(s): DABIRI N.*,MOAZEDI A.A.,GHARIB NASERI MOHAMMAD KAZEM
 
 *DEPT. OF BIOLOGY, SCHOOL OF SCIENCE, SHAHID CHAMRAN UNIVERSITY, AHWAZ
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: NO is released from ile ocolonic and induce smooth muscle relaxation. Rue (Ruta chalepensis) belongs to the Rutaceae family. Some quinoline alkaloids have spasmolytic activities. In this study the mechanism of a hydroalcoholic extract of Rue leaves has been investigated on male rat ileum.
Methods: Rue leaves were macerated in 70% ethanol. Ileum segment were removed post mortem from adult male rats in an organ bath containing Tyrode solution. Contraction was induced by KCl 60mM and Concentrations of Rue extract were (0.01- 0.07 mg/ml). L-NAME (100µM) was using inhibitory NO syntheses. Methylene blue (MB) 30µM inhibitor guanylate cyclase.
Results: Statistical comparisons showed that various concentrations of rue extract significantly (P<0.001) decreased the KCl-induced contraction. Laboratory experiments were performed to investigate mechanism of relaxation of extract Rue on smooth muscle with NO syntheses inhibitor (p<0.01). In addition blocked of guanylate cyclase by MB have significantly effect on relaxation response of Rue (P<0.01).
Conclusion: Since the present study showed that L-NAME had influence on relaxation effect of smooth muscle of ileum, therefore, it seems that the relaxation effect of Rue leaves extract was performed by cGMP syntheses.

 
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