Paper Information

Title: 

THE EFFECT OF ORAL CONSUMPTION OF SATUREJA KHUZESTANICA ESSENTIAL OIL (SKEO) ON INTESTINAL TRANSIT AND CONTRACTILITY OF ILEUM IN MICE

Type: POSTER
Author(s): PAZHOUHI N.,ASAEI R.,GHARIB NASERI MOHAMMAD KAZEM,TALEB GHOBADI A.,SALEH NIA A.N.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Satureja Khuzestanica (SK) is an annual herb that is used in the traditional medicine of Iran for treating stomach and intestinal disorders. In this study the effect of SKEO on diarrhea, intestinal transit, intestinal secretion and ileum contractility were investigated.
Method: 60 male mice divided into sham group (SG) and 7 test groups (TG 1-7) Animals in SG1 and TG1, TG2 received Tween 20 3% and SKEO1%, SKEO 2% respectively and intestinal transit and intestinal secretion were assessed. SG2 group received Tween 20 3% and TG3, TG4, TG5 received orally SKEO 1%, SKEO 2% and carvacrol 2% respectively 30 minute before castrol oil administration orally for diarrheoea induction. In TG6Atropine 0.1gr/kg was injected intra peritonealy 30 minute before castrol oil administration orally. The weight and quality of defication for 4hours were assessed. The antispasmodic activity of different dose of SKEO was assessed on contractions of isolated ileum, induced by, serotonine, Nicotine and acetylcholine.
Results: Intestinal transit and intestinal secretion in TG2 was less than SG1. SKEO decreased ileum contraction induced serotonine and acetylcholine in a concentration-dependent manner. Defication weight in TG4 (67±22.3mg) was less than SG2 (598±63.81mg), TG5 (322±47.23mg) and TG6 (326±42.79mg). defication weight in TG5 and TG6 was significantly less than SG2. There was no wet defication in TG4.
Conclusion: SK has been used orally as a herbal medicine for the treatment of gastrointestinal disturbances and is consumed as a vegetable by people every day and has no known adverse effect, so it seems to be reasonable to use this remedy instead of expensive medicines which reduce intestinal activity and have serious side effects.

 
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