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Paper Information

Title: 

INHIBITORY ACTION OF PENICILLIN ANTIBIOTICS ON THE ENKEPHALINASE ENZYME IN THE GUINEA PIG ILEUM

Type: POSTER
Author(s): EMAMI ABARGHOUEI M.*,MAHMOUDIAN M.,AKBARLOU N.,MOHAMMAD AKHAVAN M.
 
 *DEPT. OF PHARMACOLOGY, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

It has been shown by biochemical enzymatic study that Penicillin antibiotics are able to act as competitive reversible inhibitors of enkephalinas enzyme. In this study we evaluated the effect of Penicillin antibiotics on the enkephalinas enzyme in the guinea pig ileum. Guinea pig ileum was used in normal Tyrode solution. The ileum was stimulated at 0.1 HZ frequency and the isotonic contraction of this muscle was recorded by a Narco physiograph. Stimulation of guinea pig ileum at 10 HZ resulted in Naloxone sensitive depression of the twitch contractions of this muscle which shows the release of endogenous opioid peptides. After several minutes this depressive effect was reversed by enkephalinas enzyme. Addition of Penicillin antibiotics during the 10 HZ stimulation potentiated the depressive effect of endogenous opioid peptides in a dose dependent manner. IC50 of Ampicillin, Nafcillin and Cloxacillin was calculated as 4.8x10-8 M, 1.4x10-8 M, 7.4x10-9 M respectively. Our result shows that the Penicillin antibiotics potentiate the depressive effect of 10 HZ stimulation of guinea pig ileum by inhibition of enkephalinas enzyme.

 
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