Paper Information

Title: 

THE EFFECT OF GRAPE SEED EXTRACT (GSE) ON SPATIAL MEMORY IN AGED MALE RATS

Type: POSTER
Author(s): FARBOUD Y.*,SARKAKI A.,BADAVI M.
 
 *AHWAZ JONDISHAPOUR UNIVERSITY OF MEDICAL SCIENCES, PHYSIOLOGY RESEARCH CENTER
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Oxidative stress has been shown to play a major role in aging and in neurodegenerative disorders. Normal aging is commonly linked to a decline in learning and memory. Some clinical data shown that procyanidin oligomers from grape seeds are 20 times more potent than vitamin C and 50 times more potent than vitamin E. Grape seed extract has long been recognized to posses' myriads of properties, including antioxidant, anti-inflammatory, anticarcinogenic, platelet aggregation inhibiting and metal chelating capabilities, etc. Also grape seed extract (GSE) satisfies all the free radical scavenging determinants. In this study we evaluate the effect of GSE on spatial memory in aged male rats. Rats were divided into two groups (control and GSE treated) and trained in Morris water maze (MWM) task. Control rats received normal saline and treated rats received GSE (100 mg/kg) by oral gavage for 30 days. The results show that the mean latency time to find the hidden platform in GSE treated aged rats was decreased significantly (p<0.01). Our data show that administration of grape seed extract to aged rats reverses impairment of memory retention in water maze performance. The observed improvement in water maze performance may be due to the antioxidant property of polyphenols present in the grape seed extract. In conclusion, based on the results of the MWM tests using aged rats, we found that GSE had remarkable cognitive-enhancing activity.

 
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