Paper Information

Title: 

COMPARISON OF CNS DEPRESSANT EFFECTS OF KETAMINE WITH PHENOTHIAZINIC & ALKYLAMINIC ANTIHISTAMINES IN SUBLINGUAL ADMINISTRATION IN CAT

Type: POSTER
Author(s): ISA BIGLOU I.,HABIBIASL B.,SHABESTARI ASL A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Ketamine is one of injectable anesthetic drugs in animals and human that it's intestinal absorption rate is low. It's bioavailability in human with oral administration is %20.7. This drug has some side effects such as hallucination, hyper salivation, hypertension, histamine releasing effects and etc. In phenothiazinic group of H1 blocker antihistamines, Promethazine not only have anti histaminic and anti cholinergic effects but also can pass through blood-brain barrier and causes CNS suppression. Also chlorpheniramine is a most potent Alkylaminic antihistamine that has a good CNS suppression effects. Then it seems that co administration of them with ketamine cause more effective & deep CNS depression effects. The aim of this study was comparative evaluation of CNS suppression effects of liquid form of ketamine, Promethazine and chlorpheniramine in the manner of single and together in cat.
Methods: Ten cats selected randomly and received drugs first singly as sublingual spray rout. In 2nd stage they received concomitant doses of Promethazine with ketamine and chlorpheniramine with ketamine by the method mentioned above. Each animal was observed continusly by educated observer for CNS depression as graded on the behavioral scales.
Results: Almost all of the animals rejected receiving drugs in mixture of milk and meat. So for oral administration of drugs sublingual spray method used. Ketamine in different doses showed a significant dose dependent CNS depression effects. But Promethazine in highest dose (as oral spraying) could induce only a slight ataxia and Chlorpheniramine in administered doses did not cause a significant effect. Co administration of Promethazine and chlorpheniramine with ketamine improved CNS suppression effect of ketamine.
Conclusion: Results showed that administration of ketamine, Promethazine & chlorpheniramine in mixture of milk & meat is not a suitable method in cats. But a strong and long time CNS depression is achieved when they sprayed in mouth (as sublingual form).

 
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